Current Work

I am currently working on methods for the automated analysis of high-throughput, multidimensional clinical flow cytometry data.

Research Interests

Multivariate biomarker discovery for disease stratification, classification, diagnosis, prognosis, and outcome prediction.

Breast cancer and tumour-microenvironment interactions.

Statistical methods development for the analysis of high-throughput “omics” data.

Publications

Journal Articles

Finak G, Bashashati A, Brinkman R, Gottardo R. Merging mixture model components for cell population identification in high throughput flow cytometry data. Adv In Bioinformatics. vol 2009, (2009), 12 pages.

Wang Y, Roche O, Yan MS, Finak G, Evans AJ, Metcalf JL, Hast BE, Hanna SC, Wondergem B, Furge KA, Irwin MS, Kim WY, Teh BT, Grinstein S, Park M, Marsden PA, and Ohh M, Regulation of endocytosis via the oxygen-sensing pathway. Nature Medicine. (2009) March 01, pp. 1-6.

Finak G, Laferrière J, Hallett M, Park M, Le microenvironement tumorale: un nouvel outil pronostique pour le cancer du sein. Medecine Sciences. 2009 (In Press)

Finak G, Bertos N, Pepin F, Sadekova S, Souleimanova M, Zhao H, Chen H, Omeroglu O, Meterissian S, Omeroglu A, Hallett M, Park M. Stromal gene expression predicts clinical outcome in breast cancer. Nat Med (2008) vol. 14 (5) pp. 518-27

Finak G, Sadekova S, Pepin F, Hallett M, Meterissian S, Halwani F, Khetani K, Souleimanova M, Zabolotny B, Omeroglu A, Park M, Gene expression signatures of morphologically normal breast tissue identify basal-like tumors. Breast Cancer Res (2006) vol. 8 (5) pp. R58

Finak G, Godin N, Hallett M, Pepin F, Rajabi Z, Srivastava V, Tang Z. BIAS: Bioinformatics Integrated Application Software, Bioinformatics Apr 15, 2005; 21(8): 1745-6

Yee A, Chang X, Pineda Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L,Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH, An NMR Approach to Structural Proteomics, Feb 19, 2002; 99(4): 1825-30

Book Chapters

Finak G, Hallett M, Park M, Pepin F. Bioinformatics Tools for Gene-expression Studies. Ch 17, p 415-432 In: Handbook of Genome Research. 2004, Editor: CW Sensen, ISBN: 9783527313488, Publisher: WILEY-VCH Verlag GmbH

Invited Talks

Keynote Speaker: Personalizing Therapy for Triple Negative Breast Cancer. Eighth International Congress on Targeted Therapeutics in Cancer; Washington, DC. August 21-23, 2009

Automated Gating of Flow Cytometry Data via Cluster Merging. CCA 2009 Cytometry Symposium, Montreal, QC

Expression Profiling of the Breast Tumor Microenvironment. Seminaries du DESS en Bioinformatique, UQAM, Montreal, 2007.

Variance component estimation for class discovery and class distinction in microarray data. RECOMB Computational Cancer Biology, San Diego,CA. October 2007

Expression Profiling of the Breast Tumor Microenvironment, Montreal Microarray Symposium, 5th Edition, Montreal, QC. 2006